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Diagn Microbiol Infect Dis. 2012 Oct;74(2):207-9. doi: 10.1016/j.diagmicrobio.2012.06.013. Epub 2012 Jul 20.

An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis.

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Department of Clinical Microbiology, Auckland District Health Board, Auckland, New Zealand.


Recent reports suggest that false-positive rifampicin resistance may be assigned by the Xpert MTB/RIF assay. We analysed 169 specimens using the MTB/RIF assay. Using culture as the gold standard, we found that the assay had 100% sensitivity and specificity for detecting M. tuberculosis. However, we found that the assay incorrectly assigned rifampicin resistance in 4/13 (31%) of cases.

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