piRNAs and siRNAs collaborate in Caenorhabditis elegans genome defense

Genome Biol. 2012 Jul 20;13(7):164. doi: 10.1186/gb-2012-13-7-164.

Abstract

Caenorhabditis elegans piRNAs promote genome surveillance by triggering siRNA-mediated silencing of nonself DNA in competition with licensing programs that support endogenous gene expression.

Publication types

  • Introductory Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Argonaute Proteins / metabolism
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins / metabolism
  • DNA Transposable Elements
  • Epigenesis, Genetic
  • Genome, Helminth*
  • RNA, Small Interfering / metabolism*

Substances

  • Argonaute Proteins
  • Caenorhabditis elegans Proteins
  • DNA Transposable Elements
  • RNA, Small Interfering