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Learn Mem. 2012 Jul 18;19(8):337-40. doi: 10.1101/lm.026369.112.

The visual orientation memory of Drosophila requires Foraging (PKG) upstream of Ignorant (RSK2) in ring neurons of the central complex.

Author information

1
Institut für Zoologie III-Neurobiologie, Johannes-Gutenberg Universität Mainz, D-55099 Mainz, Germany.

Abstract

Orientation and navigation in a complex environment requires path planning and recall to exert goal-driven behavior. Walking Drosophila flies possess a visual orientation memory for attractive targets which is localized in the central complex of the adult brain. Here we show that this type of working memory requires the cGMP-dependent protein kinase encoded by the foraging gene in just one type of ellipsoid-body ring neurons. Moreover, genetic and epistatic interaction studies provide evidence that Foraging functions upstream of the Ignorant Ribosomal-S6 Kinase 2, thus revealing a novel neuronal signaling pathway necessary for this type of memory in Drosophila.

PMID:
22815538
PMCID:
PMC3407938
DOI:
10.1101/lm.026369.112
[Indexed for MEDLINE]
Free PMC Article

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