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Dev Cell. 2012 Jul 17;23(1):7-8. doi: 10.1016/j.devcel.2012.06.009.

Calcineurin/NFATc signaling: role in postnatal β cell development and diabetes mellitus.

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1
Institute of Metabolic Physiology and German Diabetes Center (DDZ), Heinrich Heine University, Düsseldorf, Germany.

Abstract

Pancreatic islets are aggregates of endocrine cells required for blood glucose control and diabetes prevention after birth. In this issue of Developmental Cell, Goodyer et al. (2012) reveal a function of calcineurin, a calcium-activated serine/threonine phosphatase, in postnatal NFATc-regulated expression of genes that help β cells to form insulin-containing vesicles and enter the cell cycle.

PMID:
22814597
DOI:
10.1016/j.devcel.2012.06.009
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