Format

Send to

Choose Destination
Virus Res. 2013 Feb;171(2):357-65. doi: 10.1016/j.virusres.2012.06.022. Epub 2012 Jul 16.

Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studies.

Author information

1
Molecular Virology Section 1, Laboratory of Molecular, Microbiology, The National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

RNA helicases are ubiquitous in plants and animals and function in many cellular processes. Retroviruses, such as human immunodeficiency virus (HIV-1), encode no RNA helicases in their genomes and utilize host cellular RNA helicases at various stages of their life cycle. Here, we briefly summarize the roles RNA helicases play in HIV-1 replication that have been identified recently, in part, through genome-wide screenings, proteomics, and molecular studies. Some of these helicases augment virus propagation while others apparently participate in antiviral defenses against viral replication.

PMID:
22814432
PMCID:
PMC3493675
DOI:
10.1016/j.virusres.2012.06.022
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center