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J Matern Fetal Neonatal Med. 2012 Dec;25(12):2769-72. doi: 10.3109/14767058.2012.712562. Epub 2012 Aug 22.

Relationship between the neonatal white blood cell count and histologic chorioamnionitis in preterm newborns.

Author information

1
Department of Pediatrics, Padua University, Via Giustiniani 3 35128 Padua, Italy. vincenzo.zanardo@libero.it

Abstract

OBJECTIVE:

The aim was to examine the relationship between neonatal white blood cell (WBC) count and the diagnosis of histologic chorioamnionitis (HCA).

DESIGN:

We measured WBC, a widely used marker of inflammation, to evaluate whether the values at birth were associated with HCA.

SETTING:

NICU, Department of Pediatrics of Padua University, Padua, Italy.

SUBJECTS:

WBC count was evaluated in 71 preterm neonates (<32 weeks of gestation) with HCA and in a control group without HCA on day 1, 3, and 6 after delivery. Logistic regression analysis and diagnostic accuracy analysis were used to assess the association between WBC counts and HCA.

MAIN RESULTS:

WBC levels were significantly higher in infants with HCA than in those without HCA (Median IQR, WBC (x10(9)/l): day 1, 13.2 (6.2-21.8) vs 8.1 (6-11.4), p < 0.001; day 3, 17.4 (11.4-26.9) vs 6.3 (5.2-8.3), p < 0.001; day 6, 18.4 (11.1-31) vs 6.5 (4.4-9), p < 0.0001). The neonatal WBC count on the third day of life was the most sensitive parameter associated with HCA (sensitivity: 0.80; specificity: 0.88). The cut-off value based on the ROC curve was 10 (x10(9)/l).

CONCLUSIONS:

WBC count in the third day of life is strongly associated with HCA.

PMID:
22813065
DOI:
10.3109/14767058.2012.712562
[Indexed for MEDLINE]
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