Format

Send to

Choose Destination
See comment in PubMed Commons below
Fa Yi Xue Za Zhi. 2012 Jun;28(3):190-4.

[Identification of sibling brothers using STR and Y-biallelic markers].

[Article in Chinese]

Author information

1
Furong Forensic Science Identification Center of Hunan Second People's Hospital, Changsha 410007, China. tangmeiyun2000@yahoo.com.cn

Abstract

OBJECTIVE:

To explore the methods for identification of sibling brothers with Y-STR locus mutation by detection of genetic markers on autosome and Y-biallelic.

METHODS:

Goldeneye 20A and 18NC kit were used to genotyped the 35 STRs on autosome from two men. PowerPlex Y kit and Yfiler kit were used to genotyped the 16 STRs on Y chromosome full sibling index was calculated by ITO method. Twenty Y-biallelic markers were genotyped by fragment length discrepant allele specific PCR or general PCR.

RESULTS:

Relationship of sibling brothers was found to have mutation of 2 loci on 16 Y-STR and the identical genetype of 20 Y-biallelic markers as well as a cumulative full sibling index of 4.3149 x 10(6) from 35 STRs on autosome.

CONCLUSION:

In identification of paternal linage of Y-STR mutation, more genetic information can be acquired by detection of Y-biallelic markers including SNP and InDel.

PMID:
22812220
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center