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J Pathol Inform. 2011;2:S10. doi: 10.4103/2153-3539.92035. Epub 2012 Jan 19.

Biomechanical model-based deformable registration of MRI and histopathology for clinical prostatectomy.

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Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.


A biomechanical model-based deformable image registration incorporating specimen-specific changes in material properties is optimized and evaluated for correlating histology of clinical prostatectomy specimens with in vivo MRI. In this methodology, a three-step registration based on biomechanics calculates the transformations between histology and fixed, fixed and fresh, and fresh and in vivo states. A heterogeneous linear elastic material model is constructed based on magnetic resonance elastography (MRE) results. The ex vivo tissue MRE data provide specimen-specific information for the fresh and fixed tissue to account for the changes due to fixation. The accuracy of the algorithm was quantified by calculating the target registration error (TRE) by identifying naturally occurring anatomical points within the prostate in each image. TRE were improved with the deformable registration algorithm compared to rigid registration alone. The qualitative assessment also showed a good alignment between histology and MRI after the proposed deformable registration.


Biomechanical models; correlative pathology; deformable registration; finite element model; magnetic resonance elastography

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