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Mol Imaging Biol. 2013 Apr;15(2):155-65. doi: 10.1007/s11307-012-0577-8.

Feasibility of sequential PET/MRI using a state-of-the-art small animal PET and a 1 T benchtop MRI.

Author information

1
Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany. A.Schmid@med.uni-tuebingen.de

Abstract

PURPOSE:

Combined PET/MRI studies receive increasing attention, as their combination allows deeper insight into disease progression. We evaluated a novel 1 T benchtop MRI scanner (1T-MRI) for its use in sequential PET/MRI studies.

PROCEDURES:

Phantom studies were performed, addressing the attenuation caused by the MRI coils. For in vivo studies, PET/MRI data acquired with the 1T-MRI were compared with data using a conventional small animal high-field MRI (7T-MRI) in combination with the same PET scanner.

RESULTS:

Phantom and in vivo measurements show that the animal beds have no negative impact on the PET scanner performance compared to the 7T-MRI animal bed. Representative images of various animal studies are shown, indicating a wide field for sequential PET-benchtop MRI applications.

CONCLUSION:

Phantom and in vivo data indicate that sequential PET/MRI studies with this novel setup are comparable to sequential PET/MRI studies using a 7T-MRI in combination with a dedicated PET scanner.

PMID:
22811019
DOI:
10.1007/s11307-012-0577-8
[Indexed for MEDLINE]

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