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Nat Chem Biol. 2012 Jul 18;8(8):670-3. doi: 10.1038/nchembio.1025.

A new era of GPCR structural and chemical biology.

Author information

1
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

Abstract

G protein-coupled receptors (GPCRs) are versatile molecular machines that regulate the majority of physiological responses to chemically diverse hormones and neurotransmitters. Recent breakthroughs in structural studies have advanced our understanding of GPCR signaling, particularly the selectivity of ligand recognition and receptor activation of G proteins.

PMID:
22810761
PMCID:
PMC4031315
DOI:
10.1038/nchembio.1025
[Indexed for MEDLINE]
Free PMC Article

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