A population of 100 drug addicts, two of whom were homosexual, all of them jailed has been considered. Patients were admitted on more than one occasion to a specially equipped ward for jailed patients at the "Amedeo di Savoia" of USL 4 of Turin. The clinical course of the condition brought on by HIV infection was compared with a similar sample of non-imprisoned subjects. In conclusion, some socio-assistential operative proposals for responding to the clinico-therapeutic, psychological and socio-familial needs of such patients are reported.