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Commun Integr Biol. 2012 Mar 1;5(2):190-2. doi: 10.4161/cib.18888.

The CD95 signaling pathway: To not die and fly.

Abstract

Our recent findings indicate that cells exposed to transmembrane (m-CD95L) or metalloprotease-cleaved CD95L (cl-CD95L) undergo a localized Ca(2+)entry that not only inhibits the initial steps of the CD95-mediated apoptotic signal but also promotes cell motility. Based on recent findings published on the non-apoptotic signals induced by CD95, we discuss how m-CD95L and cl-CD95L diverging by their stoichiometry could both contribute to the immune response by first recruiting activated T lymphocytes in the inflamed area and later by eliminating infected and transformed cells.

KEYWORDS:

Apoptosis; Fas; FasL; Orai1; PI3K; TNF; calcium; lymphocyte; migration

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