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PLoS One. 2012;7(7):e39782. doi: 10.1371/journal.pone.0039782. Epub 2012 Jul 11.

Drug discovery prospect from untapped species: indications from approved natural product drugs.

Author information

1
The Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, People's Republic of China.

Abstract

Due to extensive bioprospecting efforts of the past and technology factors, there have been questions about drug discovery prospect from untapped species. We analyzed recent trends of approved drugs derived from previously untapped species, which show no sign of untapped drug-productive species being near extinction and suggest high probability of deriving new drugs from new species in existing drug-productive species families and clusters. Case histories of recently approved drugs reveal useful strategies for deriving new drugs from the scaffolds and pharmacophores of the natural product leads of these untapped species. New technologies such as cryptic gene-cluster exploration may generate novel natural products with highly anticipated potential impact on drug discovery.

PMID:
22808057
PMCID:
PMC3394748
DOI:
10.1371/journal.pone.0039782
[Indexed for MEDLINE]
Free PMC Article

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