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Biologics. 2012;6:147-54. doi: 10.2147/BTT.S24155. Epub 2012 Jun 20.

Ovarian cancer: emerging molecular-targeted therapies.

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1
Rockville, MD, USA.

Abstract

With about 22,000 new cases estimated in 2012 in the US and 15,500 related deaths, ovarian cancer is a heterogeneous and aggressive disease. Even though most of patients are sensitive to chemotherapy treatment following surgery, recurring disease is almost always lethal, and only about 30% of the women affected will be cured. Thanks to a better understanding of the molecular mechanisms underlying ovarian cancer malignancy, new therapeutic options with molecular-targeted agents have become available. This review discusses the rationale behind molecular-targeted therapies and examines how newly identified molecular targets may enhance personalized therapies for ovarian cancer patients.

KEYWORDS:

BRCA; PI3K/Akt; angiogenesis; metabolism; ovarian cancer

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