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Z Rheumatol. 2012 Dec;71(10):869-73. doi: 10.1007/s00393-011-0927-y.

[Local and systemic bone effects of rheumatoid arthritis].

[Article in German]

Author information

1
Bereich Endokrinologie, Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Deutschland.

Abstract

Rheumatoid arthritis (RA) is a bone-destructive disease that is a serious risk factor for the development of osteoporosis, which is defined by a loss in bone quality and an increased fracture risk. The proinflammatory cytokines tumor necrosis factor-α (TNFα), interleukin-6 (IL-6) and IL-17, in particular, contribute to local and systemic bone loss in RA. While effectively reducing inflammation, glucocorticoids add to the fracture risk. Therefore, an adequate supply of calcium and vitamin D is essential. For many patients with RA, bone density measurements are recommended.

PMID:
22806699
DOI:
10.1007/s00393-011-0927-y
[Indexed for MEDLINE]
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