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J Comput Assist Tomogr. 2012 Jul-Aug;36(4):488-94. doi: 10.1097/RCT.0b013e31825c83c4.

Feasibility study for the improvement of microcalcification visualization in different breast thicknesses and tissue components using a dual-energy approach in digital mammography.

Author information

1
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan.

Abstract

OBJECTIVE:

The purpose of this study was to improve detectability of microcalcifications using a dual-energy digital mammographic (DEDM) technique.

METHODS:

Slabs of uniform breast-equivalent plastic and an additional plate were used to mimic various breast thicknesses, from 3 to 7 cm, and to simulate microcalcification with diameters from 0.16 to 0.39 mm. Free-response receiver operating characteristics and area under the curves (Az) were used to evaluate the sensitivity of detecting microcalcifications using the DEDM compared with using the conventional single-energy digital mammography (SEDM).

RESULTS:

The mean number of false-positives per image was 0.0198 (Az = 0.956 ± 0.027) using DEDM compared with 0.292 (Az = 0.681 ± 0.235) using SEDM. A lower radiation dose could be possibly obtained for the DEDM technique with a thickness of less than 5 cm compared with the SEDM with a thickness larger than 5 cm.

CONCLUSIONS:

Microcalcifications could be more accurately and efficiently detected using the DEDM, which might bring reliable and promising applications on early computer-aided diagnosis of breast cancer.

PMID:
22805681
DOI:
10.1097/RCT.0b013e31825c83c4
[Indexed for MEDLINE]
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