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Chem Commun (Camb). 2012 Sep 14;48(71):8864-79. doi: 10.1039/c2cc31845h. Epub 2012 Jul 17.

Imaging beyond the proteome.

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1
Department of Chemistry, University of California, Berkeley, 94720, USA.

Abstract

Imaging technologies developed in the early 20th century achieved contrast solely by relying on macroscopic and morphological differences between the tissues of interest and the surrounding tissues. Since then, there has been a movement toward imaging at the cellular and molecular level in order to visualize biological processes. This rapidly growing field is known as molecular imaging. In the last decade, many methodologies for imaging proteins have emerged. However, most of these approaches cannot be extended to imaging beyond the proteome. Here, we highlight some of the recently developed technologies that enable imaging of non-proteinaceous molecules in the cell: lipids, signalling molecules, inorganic ions, glycans, nucleic acids, small-molecule metabolites, and protein post-translational modifications such as phosphorylation and methylation.

PMID:
22801420
PMCID:
PMC3660043
DOI:
10.1039/c2cc31845h
[Indexed for MEDLINE]
Free PMC Article
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