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Peptides. 2012 Oct;37(2):207-15. doi: 10.1016/j.peptides.2012.07.001. Epub 2012 Jul 16.

Overview on the recent study of antimicrobial peptides: origins, functions, relative mechanisms and application.

Author information

1
Biopharmaceutical Research and Development Center, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China.

Abstract

Antimicrobial peptides (AMPs), which are produced by several species including insects, other animals, micro-organisms and synthesis, are a critical component of the natural defense system. With the growing problem of pathogenic organisms resistant to conventional antibiotics, especially with the emergence of NDM-1, there is increased interest in the pharmacological application of AMPs. They can protect against a broad array of infectious agents, such as bacteria, fungi, parasite, virus and cancer cells. AMPs have a very good future in the application in pharmaceuticals industry and food additive. This review focuses on the AMPs from different origins in these recent years, and discusses their various functions and relative mechanisms of action. It will provide some detailed files for clinical research of pharmaceuticals industry and food additive in application.

PMID:
22800692
DOI:
10.1016/j.peptides.2012.07.001
[Indexed for MEDLINE]

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