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Mol Cell Endocrinol. 2013 Feb 25;366(2):204-14. doi: 10.1016/j.mce.2012.06.013. Epub 2012 Jul 11.

Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity.

Author information

1
Molecular Physiology Group, The August Krogh Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark.

Abstract

The energy/fuel sensor 5'-AMP-activated protein kinase (AMPK) is viewed as a master regulator of cellular energy balance due to its many roles in glucose, lipid, and protein metabolism. In this review we focus on the regulation of AMPK activity in skeletal muscle and its involvement in glucose metabolism, including glucose transport and glycogen synthesis. In addition, we discuss the plausible interplay between AMPK and insulin signaling regulating these processes.

PMID:
22796442
DOI:
10.1016/j.mce.2012.06.013
[Indexed for MEDLINE]
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