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Mol Cell Endocrinol. 2013 Feb 25;366(2):152-62. doi: 10.1016/j.mce.2012.06.018. Epub 2012 Jul 14.

Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver.

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1
Department of Molecular Physiology and Biophysics and Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. clinton.m.hasenour@vanderbilt.edu

Abstract

This review summarizes the emerging role of AMP-activated protein kinase (AMPK) in mediating endocrine regulation of metabolic fluxes in the liver. There are a number of hormones which, when acting on the liver, alter AMPK activation. Here we describe those hormones associated with activation and de-activation of AMPK and the potential mechanisms for changes in AMPK activation state. The actions of these hormones, in many cases, are consistent with downstream effects of AMPK signaling thus strengthening the circumstantial case for AMPK-mediated hormone action. In recent years, genetic mouse models have also been used in an attempt to establish the role of AMPK in hormone-stimulated metabolism in the liver. Few experiments have, however, firmly established a causal relationship between hormone action at the liver and AMPK signaling.

PMID:
22796337
PMCID:
PMC3538936
DOI:
10.1016/j.mce.2012.06.018
[Indexed for MEDLINE]
Free PMC Article
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