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Schizophr Res. 2012 Sep;140(1-3):83-6. doi: 10.1016/j.schres.2012.06.033. Epub 2012 Jul 15.

Comparison of putative intermediate phenotypes in schizophrenia patients with and without obsessive-compulsive disorder: examining evidence for the schizo-obsessive subtype.

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1
Minneapolis Veterans Affairs Medical Center, Research 116A Building 68, One Veterans Drive, Minneapolis, MN 55417, USA. AnnaDocherty@mail.missouri.edu

Abstract

Obsessive-compulsive symptoms or obsessive-compulsive disorder (OCD) is estimated to occur in up to 30% of patients with schizophrenia. Whether this subgroup of patients is cognitively, affectively, or physiologically distinct remains unclear. 204 schizophrenia patients, 15 who also met criteria for a diagnosis of OCD, and 147 healthy controls were examined on several intermediate phenotypes. The patient groups did not differ from each other except that the co-morbid group exhibited an elevated rate of eye-tracking dysfunction. Results suggest that OCD-co-morbid patients did not comprise a distinct subgroup based on the measures studied here, although systematic assessment of larger cohorts is warranted.

PMID:
22796151
PMCID:
PMC3423524
DOI:
10.1016/j.schres.2012.06.033
[Indexed for MEDLINE]
Free PMC Article
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