Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Cell Probes. 2012 Oct;26(5):182-7. doi: 10.1016/j.mcp.2012.07.001. Epub 2012 Jul 10.

Novel molecular beacons to monitor microRNAs in non-small-cell lung cancer.

Author information

1
Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.

Abstract

Lung cancer is the leading cause of cancer death worldwide. There is no effective early diagnostic technology for lung cancer. microRNAs (miRNAs) are noncoding RNA molecules which regulate the process of cell growth and differentiation in human cancers. Hsa-miR-155 (miR-155), highly expressed in non-small-cell lung cancer (NSCLC), can be used as a diagnostic marker for NSCLC. Dynamic observation of miR-155 is critical to diagnose NSCLC. A novel molecular beacon (MB) of miR-155 was designed to image the expression of miR-155 in NSCLC. Then miR-155 was detected in vitro by laser confocal microscopy and in vivo by stereomicroscope imaging system, respectively. The present study demonstrated that intracellular miR-155 could be successfully and quickly detected by novel miR-155 MBs. As a noninvasive monitoring approach, MBs could be used to diagnose lung cancer at early stage through molecular imaging.

PMID:
22796123
DOI:
10.1016/j.mcp.2012.07.001
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center