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Bioorg Med Chem Lett. 2012 Aug 15;22(16):5204-7. doi: 10.1016/j.bmcl.2012.06.069. Epub 2012 Jun 28.

Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside.

Author information

1
Queen's University Belfast, John King Laboratory, School of Pharmacy, Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK.

Abstract

2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed.

PMID:
22795628
PMCID:
PMC3683580
DOI:
10.1016/j.bmcl.2012.06.069
[Indexed for MEDLINE]
Free PMC Article

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