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Breast. 2012 Oct;21(5):635-40. doi: 10.1016/j.breast.2012.06.009. Epub 2012 Jul 12.

Predictors of invasive breast cancer and lymph node involvement in ductal carcinoma in situ initially diagnosed by vacuum-assisted breast biopsy: experience of 733 cases.

Author information

1
Division of Breast Radiology, European Institute of Oncology, Via Ripamonti 435, Milan, Italy. chiara.trentin@ieo.it

Abstract

OBJECTIVE:

To predict presence of invasive component and nodal involvement in women diagnosed preoperatively with ductal carcinoma in situ (DCIS) by vacuum-assisted breast biopsy (VABB).

MATERIALS AND METHODS:

We retrospectively analyzed 733 patients with preoperatively diagnosed DCIS, investigating the association of clinical-radiological variables with invasive component and nodal involvement.

RESULTS:

Mammographic size >20 mm and residual lesion on post-VABB mammogram were related to invasive component (both p < 0.0001) and nodal involvement (p = 0.001, p = 0.03). Age <40 years was associated with presence of invasive component (p = 0.003). By multivariate analysis residual disease was associated with invasive component, and mammographic tumor size >20 mm with nodal involvement, both highly significant.

CONCLUSIONS:

Older age, lesion <20 mm, and no residual lesion predict absence of invasion and no nodal involvement in VABB-diagnosed DCIS. However it would be imprudent to routinely forego sentinel node biopsy in such patients as non-negligible proportions of them have invasive disease.

PMID:
22795363
DOI:
10.1016/j.breast.2012.06.009
[Indexed for MEDLINE]
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