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Antioxid Redox Signal. 2014 Jan 10;20(2):353-71. doi: 10.1089/ars.2012.4774. Epub 2012 Sep 5.

Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration.

Author information

1
1 Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California , Los Angeles, California.

Abstract

SIGNIFICANCE:

The mitochondrial energy-transducing capacity is essential for the maintenance of neuronal function, and the impairment of energy metabolism and redox homeostasis is a hallmark of brain aging, which is particularly accentuated in the early stages of neurodegenerative diseases.

RECENT ADVANCES:

The communications between mitochondria and the rest of the cell by energy- and redox-sensitive signaling establish a master regulatory device that controls cellular energy levels and the redox environment. Impairment of this regulatory devise is critical for aging and the early stages of neurodegenerative diseases.

CRITICAL ISSUES:

This review focuses on a coordinated metabolic network-cytosolic signaling, transcriptional regulation, and mitochondrial function-that controls the cellular energy levels and redox status as well as factors which impair this metabolic network during brain aging and neurodegeneration.

FUTURE DIRECTIONS:

Characterization of mitochondrial function and mitochondria-cytosol communications will provide pivotal opportunities for identifying targets and developing new strategies aimed at restoring the mitochondrial energy-redox axis that is compromised in brain aging and neurodegeneration.

PMID:
22793257
PMCID:
PMC3887431
DOI:
10.1089/ars.2012.4774
[Indexed for MEDLINE]
Free PMC Article

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