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PLoS One. 2012;7(7):e40823. doi: 10.1371/journal.pone.0040823. Epub 2012 Jul 11.

Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.

Author information

1
Department of Neurosciences, University of Mons, Mons, Belgium.

Abstract

Current thinking about LTP triggered in the area CA1 of hippocampal slices is ruled by two "dogmas": (1) A single train of high-frequency stimulation is sufficient to trigger short-lasting LTP (1-3 h), whereas multiple trains are required to induce long-lasting LTP (L-LTP, more than 4 h). (2) The development of the late phase of L-LTP requires the synthesis of new proteins. In this study, we found that a single high-frequency train could trigger an LTP lasting more than 8 h that was not affected by either anisomycin or cycloheximide (two inhibitors of protein synthesis). We ascertained that the induction of this L-LTP made use of the same mechanisms as those usually reported to be involved in LTP induction: it was dependent on NMDA receptors and on the activation of two "core" kinases, CaMKII and PI3K. These findings call into question the two "dogmas" about LTP.

PMID:
22792408
PMCID:
PMC3394721
DOI:
10.1371/journal.pone.0040823
[Indexed for MEDLINE]
Free PMC Article

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