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Biosci Biotechnol Biochem. 2012;76(6):1226-8. Epub 2012 Jun 7.

New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound.

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1
Faculty of Science, Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.

Abstract

The chronological lifespan (CLS) of budding yeast is a model for the aging of post-mitotic cells in higher eukaryotes. We report here the development of a new method to assess yeast CLS. The new assay is simple, convenient and labor-saving. We applied this new method to screen natural compounds isolated from mushrooms and discovered beauveriolide I as a potent anti-aging agent.

PMID:
22790951
DOI:
10.1271/bbb.110872
[Indexed for MEDLINE]
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