Format

Send to

Choose Destination
J Neurosci Methods. 2012 Aug 15;209(2):331-6. doi: 10.1016/j.jneumeth.2012.06.028. Epub 2012 Jul 10.

A novel touch-sensitive apparatus for behavioral studies in unrestrained squirrel monkeys.

Author information

1
Preclinical Pharmacology Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. bkangas@mclean.harvard.edu

Abstract

Despite the increasing sophistication and affordability of touch-sensitive technology, its use in the behavioral sciences has been limited. The present paper describes the design and empirical validation of a novel touch-sensitive operant conditioning chamber for use with unrestrained squirrel monkeys. In addition, results from a variant of a commonly employed animal model of learning, the repeated acquisition task, demonstrate the effectiveness of this chamber in programming an assay of complex behavior. Finally, results from a study with Δ(9)-tetrahydrocannabinol, the active ingredient in marijuana, show that its effects in this novel touchscreen chamber were consistent with its dose-related effects on learning using more conventional approaches. Overall, these studies indicate the touchscreen apparatus provides effective means for programming complex behavioral tasks to assess the effects of pharmacological agents on cognitive function.

PMID:
22790109
PMCID:
PMC3429786
DOI:
10.1016/j.jneumeth.2012.06.028
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center