Format

Send to

Choose Destination
See comment in PubMed Commons below
Expert Opin Drug Saf. 2012 Sep;11(5):753-66. doi: 10.1517/14740338.2012.705827. Epub 2012 Jul 13.

Tolerability and safety of commonly used dietary supplements and nutraceuticals with lipid-lowering effects.

Author information

  • 1Atherosclerosis and Metabolic Disease Research Unit, Internal Medicine, Aging and Kidney Diseases Department, University of Bologna, S. Orsola-Malpighi Hospital, Via Albertoni, 15, 40138 Bologna, Italy. afgcicero@cardionet.it

Abstract

INTRODUCTION:

Cardiovascular diseases are one of the highest causes of death and disability in industrialized countries, whereas a large portion of patients in primary prevention have cardiovascular disease risk factors that remain uncontrolled. Lifestyle interventions, including dietary supplementation with natural compounds possessing known lipid-lowering effects, are strongly supported by the international guidelines for cardiovascular disease prevention.

AREAS COVERED:

This review provides insights on issues concerning the safety of the most commonly used dietary supplements and nutraceuticals with demonstrated lipid-lowering actions. Soluble fibers, phytosterols, soy proteins, omega 3 polyunsaturated fatty acids, monakolines, policosanols, berberine and garlic extracts are all discussed and a specific focus has been placed on their pharmacological interactions.

EXPERT OPINION:

A relatively large amount of preclinical, epidemiological and clinical evidence has demonstrated the tolerability and safety of the most commonly used dietary supplements and nutraceuticals with demonstrated lipid-lowering action. However, for most supplements and nutraceuticals, no evidence is currently available from long-term trials on morbidity and mortality. Detailed knowledge of specific health risks and pharmacological interactions for each individual compound is needed for the management of frail patients, such as children, the elderly, patients with liver or renal failure, high-risk patients, and patients consuming numerous drugs.

PMID:
22788832
DOI:
10.1517/14740338.2012.705827
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center