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Pathophysiology of Epilepsy in Autism Spectrum Disorders.


Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

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Departments of Neurology and Pediatrics, University of Wisconsin, Madison, WI
Department of Biochemistry and Molecular Medicine, University of California, Davis, CA
Department of Molecular Biosciences, School of Veterinary Medicine and NIEHS/EPA Center for Children’s Environmental Health, University of California, Davis, CA


Epilepsy occurs frequently in individuals with autism spectrum disorders (ASD). However, the mechanisms responsible for increased seizure susceptibility in ASD are largely unknown. Clues to neural hyperexcitability in the autistic brain might be derived from disorders in which single gene mutations cause both epilepsy and an autistic phenotype, such as fragile X syndrome and tuberous sclerosis complex. This chapter summarizes current understanding of epilepsy in individuals with ASD and explores potential links between the genetic disruption of neural circuits and cellular signaling pathways that contribute to both epilepsy and ASD.

Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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