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Lab Anim Res. 2012 Jun;28(2):115-21. doi: 10.5625/lar.2012.28.2.115. Epub 2012 Jun 26.

Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats.

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Department of Pathology, Biotoxtech Co., Ltd, Ochang Scientific Industrial Complex, Cheongwon-gun, Korea.


Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 13-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 11 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 5 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gamma-glutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.


Crj:CD (SD) rat; control data; reference range; toxicology

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