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J Virol. 2012 Sep;86(18):10221-5. doi: 10.1128/JVI.00882-12. Epub 2012 Jul 11.

Hepatitis C virus infection modulates expression of interferon stimulatory gene IFITM1 by upregulating miR-130A.

Author information

1
Department of Pathology, Saint Louis University, Saint Louis, Missouri, USA.

Abstract

We have examined the underlying mechanism of hepatitis C virus (HCV)-mediated IFITM1 regulation. IFITM1 is a potential target of miR-130a. Our results demonstrated that miR-130a expression was significantly higher in HCV-infected hepatocytes and liver biopsy specimens than in controls. Introduction of anti-miR-130a in hepatocytes increased IFITM1 expression. Hepatocytes stably expressing IFITM1 reduced HCV replication. Together, these results suggested that HCV infection of hepatocytes upregulates miR-130a and that use of anti-miR-130a may have potential for restriction of HCV replication.

PMID:
22787204
PMCID:
PMC3446586
DOI:
10.1128/JVI.00882-12
[Indexed for MEDLINE]
Free PMC Article

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