Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Vaccine Immunol. 2012 Sep;19(9):1552-4. doi: 10.1128/CVI.00210-12. Epub 2012 Jul 11.

IgG antibody response to toxins A and B in patients with Clostridium difficile infection.

Author information

1
Infectious Diseases Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden. marlene.wullt@med.lu.se

Abstract

IgG antibodies against Clostridium difficile toxins A and B were followed in controls and in patients with an initial C. difficile infection (CDI). Of the 50 CDI patients, 38 were cured and 12 developed recurrence. Compared to controls, patients had significantly lower anti-toxin A and B IgGs at inclusion, but the subsequent levels rose slightly regardless of clinical outcome. The results imply that the general serum reactivity against toxins A and B in the population reduces the risk of CDI, which suggests implications for vaccine strategies.

PMID:
22787196
PMCID:
PMC3428380
DOI:
10.1128/CVI.00210-12
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center