Format

Send to

Choose Destination
See comment in PubMed Commons below
Genetics. 2012 Jul;191(3):655-69. doi: 10.1534/genetics.112.141812.

Notch and the awesome power of genetics.

Author information

1
Department of Biochemistry and Molecular Biophysics, Department of Genetics and Development, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. isg4@columbia.edu

Abstract

Notch is a receptor that mediates cell-cell interactions in animal development, and aberrations in Notch signal transduction can cause cancer and other human diseases. Here, I describe the major advances in the Notch field from the identification of the first mutant in Drosophila almost a century ago through the elucidation of the unusual mechanism of signal transduction a little over a decade ago. As an essay for the GENETICS Perspectives series, it is my personal and critical commentary as well as an historical account of discovery.

PMID:
22785620
PMCID:
PMC3389966
DOI:
10.1534/genetics.112.141812
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center