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J Heart Lung Transplant. 2012 Nov;31(11):1230-3. doi: 10.1016/j.healun.2012.05.017. Epub 2012 Jul 10.

Fatal peri-operative hyperacute graft rejection during heart transplantation related to infusion of red blood cell concentrate.

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Histocompatibility Laboratory, Nancy University Hospital, Vandoeuvre-lès-Nancy, France.


With the use of sensitive new technology, hyperacute graft rejection is currently reported as an extremely rare event due to prospective lymphocyte crossmatches and/or virtual crossmatches. In this case study we describe a case of fatal early graft failure after a cardiac transplant in a male recipient who had no anti-HLA antibodies detected before transplantation, but who received, during heart transplant surgery, a red blood cell concentrate containing high levels of graft-specific alloantibodies. In addition, we analyze the relationship between these alloantibodies and the occurrence of hyperacute allograft rejection.

[Indexed for MEDLINE]

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