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Chem Commun (Camb). 2012 Aug 25;48(66):8228-30. doi: 10.1039/c2cc31713c. Epub 2012 Jul 11.

Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation.

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  • 1Department of Chemistry, University of Minnesota, 207 Pleasant Street, S. E. Minneapolis, MN 55455, USA.

Abstract

Prenylation is an essential post-translational modification in all eukaryotes. Here we describe the synthesis of a 340-member library of peptides containing free C-termini on cellulose membranes. The resulting library was then used to probe the specificity of protein farnesyltransferase from S. cerevisiae.

PMID:
22783549
PMCID:
PMC3682486
DOI:
10.1039/c2cc31713c
[PubMed - indexed for MEDLINE]
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