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World J Gastroenterol. 2012 Jul 7;18(25):3223-34. doi: 10.3748/wjg.v18.i25.3223.

Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis.

Author information

1
Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 540-749, South Korea.

Abstract

AIM:

To determine if the fraction of Nardostachys jatamansi (NJ) has the potential to ameliorate the severity of acute pancreatitis (AP).

METHODS:

Mice were administered the biologically active fraction of NJ, i.e., the 4th fraction (NJ4), intraperitoneally, and then injected with the stable cholecystokinin analogue cerulein hourly for 6 h. Six hours after the last cerulein injection, the pancreas, lung, and blood were harvested for morphological examination, measurement of cytokine expression, and examination of neutrophil infiltration.

RESULTS:

NJ4 administration attenuated the severity of AP and lung injury associated with AP. It also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heme oxygenase-1 (HO-1). Furthermore, NJ4 and its biologically active fraction, NJ4-2 inhibited the cerulein-induced death of acinar cells by inducing HO-1 in isolated pancreatic acinar cells.

CONCLUSION:

These results suggest that NJ4 may be a candidate fraction offering protection in AP and NJ4 might ameliorate the severity of pancreatitis by inducing HO-1 expression.

KEYWORDS:

Acute pancreatitis; Cytokines; Heme oxygenase-1; Nardostachys jatamansi

PMID:
22783046
PMCID:
PMC3391759
DOI:
10.3748/wjg.v18.i25.3223
[Indexed for MEDLINE]
Free PMC Article
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