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Nat Rev Mol Cell Biol. 2012 Jul 11;13(8):499-507. doi: 10.1038/nrm3391.

H₂S signalling through protein sulfhydration and beyond.

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Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.


Hydrogen sulfide (H(2)S) has recently emerged as a mammalian gaseous messenger molecule, akin to nitric oxide and carbon monoxide. H(2)S is predominantly formed from Cys or its derivatives by the enzymes cystathionine β-synthase and cystathionine γ-lyase. One of the mechanisms by which H(2)S signals is by sulfhydration of reactive Cys residues in target proteins. Although analogous to protein nitrosylation, sulfhydration is substantially more prevalent and usually increases the catalytic activity of targeted proteins. Physiological actions of sulfhydration include the regulation of inflammation and endoplasmic reticulum stress signalling as well as of vascular tension.

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