Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2012 Jul 11;13(8):483-8. doi: 10.1038/nrm3395.

Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission.

Author information

1
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Abstract

During the final stage of cell division, the future daughter cells are physically separated through abscission. This process requires coordination of many molecular machines, including endocytic and secretory vesicle trafficking proteins as well as ESCRT (endosomal sorting complex required for transport) proteins, that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.

PMID:
22781903
PMCID:
PMC4215936
DOI:
10.1038/nrm3395
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center