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Trends Biochem Sci. 1990 Nov;15(11):425-30.

The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS.

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1
Department of Crystallography, Birkbeck College, London, UK.

Abstract

A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.

PMID:
2278102
[Indexed for MEDLINE]

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