Send to

Choose Destination
Trends Biochem Sci. 1990 Nov;15(11):425-30.

The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS.

Author information

Department of Crystallography, Birkbeck College, London, UK.


A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center