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BJOG. 2012 Aug;119(9):1029-39. doi: 10.1111/j.1471-0528.2012.03408.x.

Efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers: a meta-analysis.

Author information

1
Smoking Cessation Clinic, Family Medicine Clinic, and Centre for Cancer Prevention and Detection, National Cancer Centre, Gyeonggi-do, South Korea. msk@ncc.re.kr

Abstract

BACKGROUND:

The efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers has not yet been established.

OBJECTIVE:

To investigate the efficacy and safety of pharmacotherapy for smoking cessation among pregnant smokers.

SEARCH STRATEGY:

A search was made of PubMed, Embase and CENTRAL in June 2011.

SELECTION CRITERIA:

Randomised controlled trials (RCTs), quasi-RCTs and retrospective or prospective controlled studies were included.

DATA COLLECTION AND ANALYSIS:

The main analyses were designed to examine the efficacy of pharmacotherapy for smoking cessation among pregnant smokers based on the longest follow-up data available and from data obtained at the latest available time-point in pregnancy in each study.

MAIN RESULTS:

Of 74 articles identified from the databases, seven studies (five RCTs, one quasi-RCT and one prospective study) involving a total of 1386 pregnant smokers, 732 in the intervention groups and 654 in the control groups, were included in the final analyses. In a fixed-effects meta-analysis of all seven studies based on the longest follow-up data available, pharmacotherapy had a significant effect on smoking cessation (relative risk [RR] 1.80; 95% confidence interval [CI] 1.32-2.44). Subgroup meta-analysis by type of study design also showed similar findings for RCTs (RR 1.48; 95% CI 1.04-2.09) and other types of studies (RR 3.25; 95% CI 1.65-6.39). The abstinence rate at late pregnancy in the intervention ranged from 7 to 22.6% (mean abstinence rate 13.0%; 95% CI 10.9-15.2%). A few minor adverse effects and serious adverse effects were reported in several studies.

AUTHOR'S CONCLUSIONS:

This study indicates that there may be clinical evidence to support the use of pharmacotherapy for smoking cessation among pregnant smokers. Further RCTs are needed.

[Indexed for MEDLINE]
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