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ACS Chem Neurosci. 2011 Mar 16;2(3):118-40. doi: 10.1021/cn100100e. Epub 2011 Feb 4.

Superparamagnetic iron oxide nanoparticles: promises for diagnosis and treatment of multiple sclerosis.

Author information

1
National Cell Bank, Pasteur Institute of Iran, Tehran, 11365-8639, Iran. mahmoudi@biospion.com

Abstract

Smart superparamagnetic iron oxide nanoparticles (SPIONs) are the most promising candidate for theragnosis (i.e., diagnosis and treatment) of multiple sclerosis. A deep understanding of the dynamics of the in vivo neuropathology of multiple sclerosis can be achieved by improving the efficiency of various medical techniques (e.g., positron emission tomography and magnetic resonance imaging) using multimodal SPIONs. In this Review, recent advances and challenges in the development of smart SPIONs for theragnostic applications are comprehensively described. In addition, critical outlines of emerging developments are provided from the points of view of both clinicians and nanotechnologists.

KEYWORDS:

Superparamagnetic iron oxide nanoparticles; multimodality; multiple sclerosis; neuropathology; theragnosis

PMID:
22778862
PMCID:
PMC3369738
DOI:
10.1021/cn100100e
[Indexed for MEDLINE]
Free PMC Article
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