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ACS Chem Neurosci. 2010 Jan 20;1(1):4-12. doi: 10.1021/cn900006n. Epub 2009 Oct 9.

Intercellular glutamate signaling in the nervous system and beyond.

Author information

1
Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607.

Abstract

Most intercellular glutamate signaling in the nervous system occurs at synapses. Some intercellular glutamate signaling occurs outside synapses, however, and even outside the nervous system where high ambient extracellular glutamate might be expected to preclude the effectiveness of glutamate as an intercellular signal. Here, I briefly review the types of intercellular glutamate signaling in the nervous system and beyond, with emphasis on the diversity of signaling mechanisms and fundamental unanswered questions.

KEYWORDS:

Glutamate; paracrine; receptor; synaptic

PMID:
22778802
PMCID:
PMC3368625
DOI:
10.1021/cn900006n
[Indexed for MEDLINE]
Free PMC Article
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