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Mediators Inflamm. 2012;2012:946813. doi: 10.1155/2012/946813. Epub 2012 Jun 18.

Role of prostaglandins in neuroinflammatory and neurodegenerative diseases.

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1
Department of Pharmacology, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, 31270-901 Belo Horizonte, MG, Brazil.

Abstract

Increasing data demonstrates that inflammation participates in the pathophysiology of neurodegenerative diseases. Among the different inflammatory mediators involved, prostaglandins play an important role. The effects induced by prostaglandins might be mediated by activation of their known receptors or by nonclassical mechanisms. In the present paper, we discuss the evidences that link prostaglandins, as well as the enzymes that produce them, to some neurological diseases.

PMID:
22778499
PMCID:
PMC3385693
DOI:
10.1155/2012/946813
[Indexed for MEDLINE]
Free PMC Article
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