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BMJ Case Rep. 2010 Sep 29;2010. pii: bcr0120102661. doi: 10.1136/bcr.01.2010.2661.

Fulminant hepatic failure in a patient with advanced extragonadal germ cell tumour.

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1
Department of Medical Oncology, St James's Institute of Oncology, Leeds, UK.

Abstract

Fulminant hepatic failure (FHF) in association with metastatic cancer, without evidence of liver metastases, has not been previously reported in the literature. This report concerns a case of FHF in a 36-year-old man with advanced germ cell tumour arising from an extragonadal (retroperitoneal) primary. Liver function and encephalopathy improved following chemotherapy, suggesting prompt diagnosis and treatment may have cured the patient. Following completion of chemotherapy, he developed spontaneous bacterial endocarditis, requiring aortic valve replacement, a rare complication of curative chemotherapy. At 44 months post completion of chemotherapy, he has regained his premorbid performance status and has returned to work.

PMID:
22778367
PMCID:
PMC3027936
DOI:
10.1136/bcr.01.2010.2661
[Indexed for MEDLINE]
Free PMC Article
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