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Swiss Med Wkly. 2012 Jul 9;142:w13618. doi: 10.4414/smw.2012.13618.

Modeling HIV infection and therapies in humanized mice.

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1
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, University of Zurich, Switzerland. marc.nischang@usz.ch

Abstract

The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection.

PMID:
22777836
DOI:
10.4414/smw.2012.13618
[Indexed for MEDLINE]
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