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Curr Diab Rep. 2012 Oct;12(5):580-6. doi: 10.1007/s11892-012-0296-1.

No islets left behind: islet autotransplantation for surgery-induced diabetes.

Author information

1
University of Minnesota Amplatz Children's Hospital, Minneapolis, MN 55454, USA. bell0130@umn.edu

Abstract

For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preserve some endogenous islet function in the majority of recipients, which mediates protection against brittle diabetes. Most maintain reasonably good glycemic control, while 30 %-40 % successfully discontinue insulin therapy. With islet autotransplants reaching a wider clinical audience, refinements in islet isolation techniques and strategies to protect islet grafts post-transplant may further improve the success of this procedure.

PMID:
22777430
PMCID:
PMC3432727
DOI:
10.1007/s11892-012-0296-1
[Indexed for MEDLINE]
Free PMC Article
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