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Brain Stimul. 2013 May;6(3):306-9. doi: 10.1016/j.brs.2012.05.010. Epub 2012 Jun 15.

A comparison of two methods in acquiring stimulus-response curves with transcranial magnetic stimulation.

Author information

1
Cognitive and Exercise Neuroscience Unit, School of Psychology, Deakin University, Melbourne, Victoria, Australia. alan.pearce@deakin.edu.au

Abstract

BACKGROUND:

The stimulus-response (S-R) curve is a well accepted constituent in transcranial magnetic stimulation (TMS) studies. However, it has been suggested that parameters of the S-R curve differ when stimuli are provided in a "ramped" (measured steps from low to high intensity), or "random" fashion.

HYPOTHESIS:

We hypothesized that there would be no difference in the parameters of the S-R curve between either methodologies.

METHODS:

Using a randomised cross-over design, 10 healthy participants (29.6 ± 6.4 yrs, 3 f) completed "ramped" or "random" curves in biceps brachii (BB) and first dorsal interosseous (FDI) muscles of both limbs. Curves were compared using mixed-factor ANOVA and correlated between limbs and methodologies.

RESULTS:

No differences (P > 0.05) and high correlations (range 0.71-0.97; P < 0.001) were observed in BB and FDI data between curves.

CONCLUSIONS:

This study demonstrated that either methodology provides similar parameters of the S-R curve in healthy participants.

PMID:
22776698
DOI:
10.1016/j.brs.2012.05.010
[Indexed for MEDLINE]

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