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Gulf J Oncolog. 2012 Jul;(12):55-8.

Mixed germ cell tumor of ovary and clitoromegaly in Swyer's syndrome: a case report.

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Department of Obstetric and Gynecology, Tehran University of Medical Sciences, Islamic Republic of Iran.


Swyer syndrome is a type of pure gonadal dysgenesis correlating with 46 XY karyotype, primary amenorrhea, and female internal and external genitalia. It reveals a testicular differentiation abnormality.A 16-year old girl admitted to our center with primary amenorrhea and abdominal mass. In spite of the absence of normal testis, clitoromegaly was noticed. Peripheral blood karyotype analysis showed 46 XY. Histopathology of the excised gonads determined mixed germ cell tumor in right ovary and streak left gonad without gonadoblastoma in left side. In patients suffering from Swyer syndrome, high risk of gonadal neoplasia dictates early prophylactic gonadal excision to lengthen survival.

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