Send to

Choose Destination
J Neuropsychiatry Clin Neurosci. 2012 Spring;24(2):176-82. doi: 10.1176/appi.neuropsych.11080189.

Bilateral anterior capsulotomy for intractable depression.

Author information

Department of Surgery, University of British Columbia, and Department of Psychiatry, UBC Hospital, Vancouver, BC, Canada.


A group of eight patients with severe depression lasting 6 years or longer were treated with anterior capsulotomy and followed prospectively. Stereotactic surgery was used to produce radiofrequency lesions in the anterior limbs of both internal capsules. For all patients, there are follow-up data for at least 24 months. At 24-to-36 months postoperatively, four patients were either not-depressed or mildly depressed; one was mildly-to-moderately depressed; one was moderately-to-severely depressed; and only one remained severely depressed. One patient developed a progressive vascular dementia with parkinsonism caused by autopsy-proven arteriolosclerosis.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center